It happened near Exit 22 northbound just after midnight.
State police say the accident involved two cars and a tractor-trailer.
They say a Chevrolet in the center lane spun out for an unknown reason and collided with the concrete barrier.
A BMW hit the car as a result.
The driver of the Chevrolet, William Foster, of Bridgeport, was ejected from the vehicle.
Meanwhile, a tractor-trailer hit the Chevrolet and also collided into the barrier.
Both Foster and the tractor-trailer driver were pronounced dead at the scene.
The highway reopened just before 7 a.m.
Anyone with information is asked to contact state police.